Postdoctoral Fellow (Immunogenomics in Chronic Respiratory Diseases)

Company: San Diego BioMed
Location: San Diego
Posted on: October 31, 2024

Job Description:

About San Diego BioMedSan Diego BioMed (SDB) is a nonprofit biomedical research institute located in San Diego, California. The mission of SDB is to conduct fundamental biomedical research to better understand human disease and to use this information to contribute to the treatment and prevention of diabetes, cancer, neurological disease, HIV infection, asthma and respiratory allergies, and complications of chronic diseases. The Principal Investigators at SDB are accomplished scientists, recognized in their areas of expertise. Our labs are equipped with state-of-the-art equipment. SDB is in the heart of San Diego's science park area, which is part of the largest and most concentrated centers of science, engineering, and medicine in the United States. Further information on SDB can be found at .Position OverviewThe Immunogenomics Lab in Chronic Respiratory Diseases at San Diego BioMed, led by Dr. Seumois, is seeking a passionate and driven Postdoctoral Fellow to join his research team. The Seumois Lab focuses on understanding immune cell diversity and function in the context of asthma and allergic diseases, with a special emphasis on novel CD4 T cell subsets characterized by strong type 1 Interferon response, called THIFNR cells (Seumois et al. Sc. Immunol., 2020). The position involves using both in vivo pre-clinical models of asthma and primary human cell culture assays to better characterize these THIFNR cells as well as elucidate their function and ontogeny.Our research utilizes cutting-edge genomic and functional techniques such as single-cell RNA sequencing (scRNA-seq), scATAC-seq, scTCR-seq, CRISPR, and advanced flow cytometry to investigate disease biology.Key Objectives:

• Develop creative tools to investigate the function of THIFNR cells using in vivo models of Asthma (NIH-R01AI163665).
• Develop creative tools to investigate in vitro models using primary human immune cells to validate THIFNR cells function and investigate their lineage commitment and molecular heterogeneity (NIH-R21AI173884).Selected Publications from our Lab:
• Herrera-De La Mata et al. Cytotoxic CD4+ tissue-resident memory T cells and asthma severity. Med, 2023.
• Seumois G et al. Single-cell transcriptomics of allergen-specific T cells in asthma. Sci Immunol, 2020.Minimum RequirementsEducation & Experience:

• Ph.D. in Immunology, Molecular Biology, or a related field.Technical Skills:
  • Strong knowledge of cellular and molecular human immunology.
  • Expertise in flow cytometry (including use of FloJo software), Omics technologies (10X Genomics suite), CRISPR technologies, and tissue culture techniques (BSL2 conditions).
  • Familiarity with in vivo models of asthma/allergy.
  • Knowledge of type I interferon biology.
  • Basic coding skills in Python or R (preferred but not required).Soft Skills & Attributes:
    • Independent, organized, and detail oriented.
    • Excellent record-keeping skills (maintaining lab notebooks).
    • Strong communication skills to effectively present data in meetings and presentations.
    • Team player with a collaborative mindset, contributing positively to the lab's cooperative environment.Salary Range: $68,700 - $75,000Benefits: San Diego BioMed offers a comprehensive benefits package, including medical, dental, vision, life insurance, long-term disability, paid time off, and a competitive retirement plan. The institute fosters an inclusive and collaborative research environment.To apply for the position, candidates must provide the following:
      • A detailed resume/CV, including academic grades, honors and awards, summary of research activities, list of scientific publications (including posters, papers, and oral presentations).
      • A cover letter outlining the candidate's motivations for joining the lab.
      • A diversity statement (up to 200 words), describing the candidate's commitment to fostering a diverse and inclusive environment.
      • A career development statement (up to 500 words) outlining future professional goals and how the position aligns with the candidate's long-term aspirations.
      • Contact information for up to three professional references.Shortlisted candidates may be asked to present their PhD or early post-doctoral research in the format of a scientific seminar.We welcome applications from both domestic and international candidates, and we encourage individuals from diverse backgrounds to apply.San Diego BioMed is committed to a policy of equal employment opportunity in regard to recruiting, hiring, training and promoting the most qualified individuals, without regard to race, color, creed, religion, sex, sexual orientation, gender, gender identity and expression, marital status, age, registered domestic partner status, national origin or ancestry, physical or mental disability, age, disability, protected veteran status, medical condition including genetic characteristics, or any other protected status as designed by federal, state, or local law.
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Keywords: San Diego BioMed, El Centro , Postdoctoral Fellow (Immunogenomics in Chronic Respiratory Diseases), Healthcare , San Diego, California