Senior Scientist, Protein Homeostasis Cell Biology
Company: Disability Solutions
Location: San Diego
Posted on: October 19, 2024
Job Description:
Working with UsChallenging. Meaningful. Life-changing. Those
aren't words that are usually associated with a job. But working at
Bristol Myers Squibb is anything but usual. Here, uniquely
interesting work happens every day, in every department. From
optimizing a production line to the latest breakthroughs in cell
therapy, this is work that transforms the lives of patients, and
the careers of those who do it. You'll get the chance to grow and
thrive through opportunities uncommon in scale and scope, alongside
high-achieving teams rich in diversity. Take your career farther
than you thought possible.Bristol Myers Squibb recognizes the
importance of balance and flexibility in our work environment. We
offer a wide variety of competitive benefits, services and programs
that provide our employees with the resources to pursue their
goals, both at work and in their personal lives. Read more: .The
Oncogenesis Thematic Research Center at BMS is one of the
fundamental research and development engines delivering oncology
therapeutics to patients. With a major focus of exploiting BMS'
expertise in protein degradation, we discover and develop therapies
aimed at tumor intrinsic vulnerabilities and mechanisms of
resistance, targeting protein classes that were previously deemed
undruggable.The Protein Homeostasis (PH) Group within the
Oncogenesis TRC is focused on investigating and developing novel
approaches to manipulate proteostatic processes for therapeutic
benefit. We are seeking a skilled and passionate cell biologist to
join us in this innovative research and in the advancement of new
classes of oncology therapeutics to the clinic. The successful
candidate will, working with a multidisciplinary team of discovery
scientists, design and execute in vitro studies that further our
understanding of how proteostatic mechanisms can be co-opted to
exploit vulnerabilities of difficult-to-treat
cancers.Responsibilities will include the following:
- Plan, execute, and report on molecular and cellular biology
studies to characterize the mechanism of action of targeted protein
degraders and other induced protein proximity agents.
- Lead biology project(s) pursuing novel therapeutic targets
and/or modes of targeted protein degradation.
- Participate in multidisciplinary working groups to develop and
apply new methods and technologies to accelerate PH research.
- Collaborate with other oncology discovery scientists to advance
early concepts to robust IND-enabling packages.
- Represent the PH biology group on project teams and at
departmental meetings.
- Supervise and mentor early career scientists within the PH
group.Basic Qualifications:
- Bachelor's Degree
- 7+ years of academic and / or industry experienceOr
- Master's Degree
- 5+ years of academic and / or industry experienceOr
- Ph.D. or equivalent advanced degree in the Life Sciences
- 2+ of academic and / or industry experiencePreferred
Qualifications:
- Deep expertise in contemporary molecular and cellular biology
practices, techniques, and instrumentation.
- Extensive experience in cell-based assay development, with a
working knowledge of biochemical, biophysical, and 'omics
assays.
- Demonstrable track record of rigorous and creative research,
characterizing molecular mechanisms and/or cellular signaling
pathways in mammalian systems.
- Experience in the ubiquitin-proteasome system, protein quality
control pathways, and/or cancer biology are a plus.
- Proficiency with scientific data analysis tools and biological
statistics.
- Strong written and oral communication skills.
- Ability to work in a fast-paced and collaborative team
environment, and with adaptability in accordance with research
program needs.The starting compensation for this job is a range
from $109,000 - $150,700 plus incentive cash and stock
opportunities (based on eligibility).The starting pay rate takes
into account characteristics of the job, such as required skills
and where the job is performed.Final, individual compensation will
be decided based on demonstrated experience.Eligibility for
specific benefits listed on our careers site may vary based on the
job and location. For more on benefits, please visit our BMS Career
Site.Benefit offerings are subject to the terms and conditions of
the applicable plans then in effect and may include the following:
Medical, pharmacy, dental and vision care. Wellbeing support such
as the BMS Living Life Better program and employee assistance
programs (EAP). Financial well-being resources and a 401(K).
Financial protection benefits such as short- and long-term
disability, life insurance, supplemental health insurance, business
travel protection and survivor support. Work-life programs include
paid national holidays and optional holidays, Global Shutdown days
between Christmas and New Year's holiday, up to 120 hours of paid
vacation, up to two (2) paid days to volunteer, sick time off, and
summer hours flexibility. Parental, caregiver, bereavement, and
military leave. Family care services such as adoption and surrogacy
reimbursement, fertility/infertility benefits, support for
traveling mothers, and child, elder and pet care resources. Other
perks like tuition reimbursement and a recognition
program.#LI-OnsiteIf you come across a role that intrigues you but
doesn't perfectly line up with your resume, we encourage you to
apply anyway. You could be one step away from work that will
transform your life and career. Uniquely Interesting Work,
Life-changing CareersWith a single vision as inspiring as
Transforming patients' lives through science--- , every BMS
employee plays an integral role in work that goes far beyond
ordinary. Each of us is empowered to apply our individual talents
and unique perspectives in an inclusive culture, promoting
diversity in clinical trials, while our shared values of passion,
innovation, urgency, accountability, inclusion and integrity bring
out the highest potential of each of our colleagues.On-site
Protocol BMS has a diverse occupancy structure that determines
where an employee is required to conduct their work. This structure
includes site-essential, site-by-design, field-based and
remote-by-design jobs. The occupancy type that you are assigned is
determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned
facility. Site-by-design roles may be eligible for a hybrid work
model with at least 50% onsite at your assigned facility. For these
roles, onsite presence is considered an essential job function and
is critical to collaboration, innovation, productivity, and a
positive Company culture. For field-based and remote-by-design
roles the ability to physically travel to visit customers, patients
or business partners and to attend meetings on behalf of BMS as
directed is an essential job function. BMS is dedicated to ensuring
that people with disabilities can excel through a transparent
recruitment process, reasonable workplace
accommodations/adjustments and ongoing support in their roles.
Applicants can request a reasonable workplace
accommodation/adjustment prior to accepting a job offer. If you
require reasonable accommodations/adjustments in completing this
application, or in any part of the recruitment process, direct your
inquiries to . Visit to access our complete Equal Employment
Opportunity statement. BMS cares about your well-being and the
well-being of our staff, customers, patients, and communities. As a
result, the Company strongly recommends that all employees be fully
vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest
and conviction records, pursuant to applicable laws in your area.If
you live in or expect to work from Los Angeles County if hired for
this position, please visit this page for important additional
information: Any data processed in connection with role
applications will be treated in accordance with applicable data
privacy policies and regulations.
Keywords: Disability Solutions, El Centro , Senior Scientist, Protein Homeostasis Cell Biology, Other , San Diego, California
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